/*
 * Jalview - A Sequence Alignment Editor and Viewer (2.11.2.6)
 * Copyright (C) 2023 The Jalview Authors
 * 
 * This file is part of Jalview.
 * 
 * Jalview is free software: you can redistribute it and/or
 * modify it under the terms of the GNU General Public License 
 * as published by the Free Software Foundation, either version 3
 * of the License, or (at your option) any later version.
 *  
 * Jalview is distributed in the hope that it will be useful, but 
 * WITHOUT ANY WARRANTY; without even the implied warranty 
 * of MERCHANTABILITY or FITNESS FOR A PARTICULAR 
 * PURPOSE.  See the GNU General Public License for more details.
 * 
 * You should have received a copy of the GNU General Public License
 * along with Jalview.  If not, see <http://www.gnu.org/licenses/>.
 * The Jalview Authors are detailed in the 'AUTHORS' file.
 */
/*
 * This extension was written by Benjamin Schuster-Boeckler at sanger.ac.uk
 */
package jalview.io;

import java.io.BufferedReader;
import java.io.FileReader;
import java.io.IOException;
import java.util.ArrayList;
import java.util.Enumeration;
import java.util.Hashtable;
import java.util.LinkedHashMap;
import java.util.List;
import java.util.Locale;
import java.util.Map;
import java.util.Vector;

import com.stevesoft.pat.Regex;

import fr.orsay.lri.varna.exceptions.ExceptionUnmatchedClosingParentheses;
import fr.orsay.lri.varna.factories.RNAFactory;
import fr.orsay.lri.varna.models.rna.RNA;
import jalview.analysis.Rna;
import jalview.datamodel.AlignmentAnnotation;
import jalview.datamodel.AlignmentI;
import jalview.datamodel.Annotation;
import jalview.datamodel.DBRefEntry;
import jalview.datamodel.DBRefSource;
import jalview.datamodel.Mapping;
import jalview.datamodel.Sequence;
import jalview.datamodel.SequenceFeature;
import jalview.datamodel.SequenceI;
import jalview.schemes.ResidueProperties;
import jalview.util.Comparison;
import jalview.util.DBRefUtils;
import jalview.util.Format;
import jalview.util.MessageManager;

/**
 * This class is supposed to parse a Stockholm format file into Jalview There
 * are TODOs in this class: we do not know what the database source and version
 * is for the file when parsing the #GS= AC tag which associates accessions with
 * sequences. Database references are also not parsed correctly: a separate
 * reference string parser must be added to parse the database reference form
 * into Jalview's local representation.
 * 
 * @author bsb at sanger.ac.uk
 * @author Natasha Shersnev (Dundee, UK) (Stockholm file writer)
 * @author Lauren Lui (UCSC, USA) (RNA secondary structure annotation import as
 *         stockholm)
 * @author Anne Menard (Paris, FR) (VARNA parsing of Stockholm file data)
 * @version 0.3 + jalview mods
 * 
 */
public class StockholmFile extends AlignFile
{
  private static final String ANNOTATION = "annotation";

  // private static final Regex OPEN_PAREN = new Regex("(<|\\[)", "(");
  //
  // private static final Regex CLOSE_PAREN = new Regex("(>|\\])", ")");

  public static final Regex DETECT_BRACKETS = new Regex(
          "(<|>|\\[|\\]|\\(|\\)|\\{|\\})");

  // WUSS extended symbols. Avoid ambiguity with protein SS annotations by using
  // NOT_RNASS first.
  public static final String RNASS_BRACKETS = "<>[](){}AaBbCcDdEeFfGgHhIiJjKkLlMmNnOoPpQqRrSsTtUuVvWwXxYyZz";

  // use the following regex to decide an annotations (whole) line is NOT an RNA
  // SS (it contains only E,H,e,h and other non-brace/non-alpha chars)
  private static final Regex NOT_RNASS = new Regex(
          "^[^<>[\\](){}ADFJ-RUVWYZadfj-ruvwyz]*$");

  StringBuffer out; // output buffer

  AlignmentI al;

  public StockholmFile()
  {
  }

  /**
   * Creates a new StockholmFile object for output.
   */
  public StockholmFile(AlignmentI al)
  {
    this.al = al;
  }

  public StockholmFile(String inFile, DataSourceType type)
          throws IOException
  {
    super(inFile, type);
  }

  public StockholmFile(FileParse source) throws IOException
  {
    super(source);
  }

  @Override
  public void initData()
  {
    super.initData();
  }

  /**
   * Parse a file in Stockholm format into Jalview's data model using VARNA
   * 
   * @throws IOException
   *           If there is an error with the input file
   */
  public void parse_with_VARNA(java.io.File inFile) throws IOException
  {
    FileReader fr = null;
    fr = new FileReader(inFile);

    BufferedReader r = new BufferedReader(fr);
    List<RNA> result = null;
    try
    {
      result = RNAFactory.loadSecStrStockholm(r);
    } catch (ExceptionUnmatchedClosingParentheses umcp)
    {
      errormessage = "Unmatched parentheses in annotation. Aborting ("
              + umcp.getMessage() + ")";
      throw new IOException(umcp);
    }
    // DEBUG System.out.println("this is the secondary scructure:"
    // +result.size());
    SequenceI[] seqs = new SequenceI[result.size()];
    String id = null;
    for (int i = 0; i < result.size(); i++)
    {
      // DEBUG System.err.println("Processing i'th sequence in Stockholm file")
      RNA current = result.get(i);

      String seq = current.getSeq();
      String rna = current.getStructDBN(true);
      // DEBUG System.out.println(seq);
      // DEBUG System.err.println(rna);
      int begin = 0;
      int end = seq.length() - 1;
      id = safeName(getDataName());
      seqs[i] = new Sequence(id, seq, begin, end);
      String[] annot = new String[rna.length()];
      Annotation[] ann = new Annotation[rna.length()];
      for (int j = 0; j < rna.length(); j++)
      {
        annot[j] = rna.substring(j, j + 1);

      }

      for (int k = 0; k < rna.length(); k++)
      {
        ann[k] = new Annotation(annot[k], "",
                Rna.getRNASecStrucState(annot[k]).charAt(0), 0f);

      }
      AlignmentAnnotation align = new AlignmentAnnotation("Sec. str.",
              current.getID(), ann);

      seqs[i].addAlignmentAnnotation(align);
      seqs[i].setRNA(result.get(i));
      this.annotations.addElement(align);
    }
    this.setSeqs(seqs);

  }

  /**
   * Parse a file in Stockholm format into Jalview's data model. The file has to
   * be passed at construction time
   * 
   * @throws IOException
   *           If there is an error with the input file
   */
  @Override
  public void parse() throws IOException
  {
    StringBuffer treeString = new StringBuffer();
    String treeName = null;
    // --------------- Variable Definitions -------------------
    String line;
    String version;
    // String id;
    Hashtable seqAnn = new Hashtable(); // Sequence related annotations
    LinkedHashMap<String, String> seqs = new LinkedHashMap<>();
    Regex p, r, rend, s, x;
    // Temporary line for processing RNA annotation
    // String RNAannot = "";

    // ------------------ Parsing File ----------------------
    // First, we have to check that this file has STOCKHOLM format, i.e. the
    // first line must match

    r = new Regex("# STOCKHOLM ([\\d\\.]+)");
    if (!r.search(nextLine()))
    {
      throw new IOException(MessageManager
			    .getString("exception.stockholm_invalid_format") +" ("+r+")");
    }
    else
    {
      version = r.stringMatched(1);

      // logger.debug("Stockholm version: " + version);
    }

    // We define some Regexes here that will be used regularily later
    rend = new Regex("^\\s*\\/\\/"); // Find the end of an alignment
    p = new Regex("(\\S+)\\/(\\d+)\\-(\\d+)"); // split sequence id in
    // id/from/to
    s = new Regex("(\\S+)\\s+(\\S*)\\s+(.*)"); // Parses annotation subtype
    r = new Regex("#=(G[FSRC]?)\\s+(.*)"); // Finds any annotation line
    x = new Regex("(\\S+)\\s+(\\S+)"); // split id from sequence

    // Convert all bracket types to parentheses (necessary for passing to VARNA)
    Regex openparen = new Regex("(<|\\[)", "(");
    Regex closeparen = new Regex("(>|\\])", ")");

    // // Detect if file is RNA by looking for bracket types
    // Regex detectbrackets = new Regex("(<|>|\\[|\\]|\\(|\\))");

    rend.optimize();
    p.optimize();
    s.optimize();
    r.optimize();
    x.optimize();
    openparen.optimize();
    closeparen.optimize();

    while ((line = nextLine()) != null)
    {
      if (line.length() == 0)
      {
        continue;
      }
      if (rend.search(line))
      {
        // End of the alignment, pass stuff back
        this.noSeqs = seqs.size();

        String dbsource = null;
        Regex pf = new Regex("PF[0-9]{5}(.*)"); // Finds AC for Pfam
        Regex rf = new Regex("RF[0-9]{5}(.*)"); // Finds AC for Rfam
        if (getAlignmentProperty("AC") != null)
        {
          String dbType = getAlignmentProperty("AC").toString();
          if (pf.search(dbType))
          {
            // PFAM Alignment - so references are typically from Uniprot
            dbsource = "PFAM";
          }
          else if (rf.search(dbType))
          {
            dbsource = "RFAM";
          }
        }
        // logger.debug("Number of sequences: " + this.noSeqs);
        for (Map.Entry<String, String> skey : seqs.entrySet())
        {
          // logger.debug("Processing sequence " + acc);
          String acc = skey.getKey();
          String seq = skey.getValue();
          if (maxLength < seq.length())
          {
            maxLength = seq.length();
          }
          int start = 1;
          int end = -1;
          String sid = acc;
          /*
           * Retrieve hash of annotations for this accession Associate
           * Annotation with accession
           */
          Hashtable accAnnotations = null;

          if (seqAnn != null && seqAnn.containsKey(acc))
          {
            accAnnotations = (Hashtable) seqAnn.remove(acc);
            // TODO: add structures to sequence
          }

          // Split accession in id and from/to
          if (p.search(acc))
          {
            sid = p.stringMatched(1);
            start = Integer.parseInt(p.stringMatched(2));
            end = Integer.parseInt(p.stringMatched(3));
          }
          // logger.debug(sid + ", " + start + ", " + end);

          Sequence seqO = new Sequence(sid, seq, start, end);
          // Add Description (if any)
          if (accAnnotations != null && accAnnotations.containsKey("DE"))
          {
            String desc = (String) accAnnotations.get("DE");
            seqO.setDescription((desc == null) ? "" : desc);
          }
          // Add DB References (if any)
          if (accAnnotations != null && accAnnotations.containsKey("DR"))
          {
            String dbr = (String) accAnnotations.get("DR");
            if (dbr != null && dbr.indexOf(";") > -1)
            {
              String src = dbr.substring(0, dbr.indexOf(";"));
              String acn = dbr.substring(dbr.indexOf(";") + 1);
              jalview.util.DBRefUtils.parseToDbRef(seqO, src, "0", acn);
            }
          }

          if (accAnnotations != null && accAnnotations.containsKey("AC"))
          {
            String dbr = (String) accAnnotations.get("AC");
            if (dbr != null)
            {
              // we could get very clever here - but for now - just try to
              // guess accession type from type of sequence, source of alignment
              // plus
              // structure
              // of accession
              guessDatabaseFor(seqO, dbr, dbsource);
            }
            // else - do what ? add the data anyway and prompt the user to
            // specify what references these are ?
          }

          Hashtable features = null;
          // We need to adjust the positions of all features to account for gaps
          try
          {
            features = (Hashtable) accAnnotations.remove("features");
          } catch (java.lang.NullPointerException e)
          {
            // loggerwarn("Getting Features for " + acc + ": " +
            // e.getMessage());
            // continue;
          }
          // if we have features
          if (features != null)
          {
            int posmap[] = seqO.findPositionMap();
            Enumeration i = features.keys();
            while (i.hasMoreElements())
            {
              // TODO: parse out secondary structure annotation as annotation
              // row
              // TODO: parse out scores as annotation row
              // TODO: map coding region to core jalview feature types
              String type = i.nextElement().toString();
              Hashtable content = (Hashtable) features.remove(type);

              // add alignment annotation for this feature
              String key = type2id(type);

              /*
               * have we added annotation rows for this type ?
               */
              boolean annotsAdded = false;
              if (key != null)
              {
                if (accAnnotations != null
                        && accAnnotations.containsKey(key))
                {
                  Vector vv = (Vector) accAnnotations.get(key);
                  for (int ii = 0; ii < vv.size(); ii++)
                  {
                    annotsAdded = true;
                    AlignmentAnnotation an = (AlignmentAnnotation) vv
                            .elementAt(ii);
                    seqO.addAlignmentAnnotation(an);
                    annotations.add(an);
                  }
                }
              }

              Enumeration j = content.keys();
              while (j.hasMoreElements())
              {
                String desc = j.nextElement().toString();
                if (ANNOTATION.equals(desc) && annotsAdded)
                {
                  // don't add features if we already added an annotation row
                  continue;
                }
                String ns = content.get(desc).toString();
                char[] byChar = ns.toCharArray();
                for (int k = 0; k < byChar.length; k++)
                {
                  char c = byChar[k];
                  if (!(c == ' ' || c == '_' || c == '-' || c == '.')) // PFAM
                  // uses
                  // '.'
                  // for
                  // feature
                  // background
                  {
                    int new_pos = posmap[k]; // look up nearest seqeunce
                    // position to this column
                    SequenceFeature feat = new SequenceFeature(type, desc,
                            new_pos, new_pos, null);

                    seqO.addSequenceFeature(feat);
                  }
                }
              }

            }

          }
          // garbage collect

          // logger.debug("Adding seq " + acc + " from " + start + " to " + end
          // + ": " + seq);
          this.seqs.addElement(seqO);
        }
        return; // finished parsing this segment of source
      }
      else if (!r.search(line))
      {
        // System.err.println("Found sequence line: " + line);

        // Split sequence in sequence and accession parts
        if (!x.search(line))
        {
          // logger.error("Could not parse sequence line: " + line);
          throw new IOException(MessageManager.formatMessage(
                  "exception.couldnt_parse_sequence_line", new String[]
                  { line }));
        }
        String ns = seqs.get(x.stringMatched(1));
        if (ns == null)
        {
          ns = "";
        }
        ns += x.stringMatched(2);

        seqs.put(x.stringMatched(1), ns);
      }
      else
      {
        String annType = r.stringMatched(1);
        String annContent = r.stringMatched(2);

        // System.err.println("type:" + annType + " content: " + annContent);

        if (annType.equals("GF"))
        {
          /*
           * Generic per-File annotation, free text Magic features: #=GF NH
           * <tree in New Hampshire eXtended format> #=GF TN <Unique identifier
           * for the next tree> Pfam descriptions: 7. DESCRIPTION OF FIELDS
           * 
           * Compulsory fields: ------------------
           * 
           * AC Accession number: Accession number in form PFxxxxx.version or
           * PBxxxxxx. ID Identification: One word name for family. DE
           * Definition: Short description of family. AU Author: Authors of the
           * entry. SE Source of seed: The source suggesting the seed members
           * belong to one family. GA Gathering method: Search threshold to
           * build the full alignment. TC Trusted Cutoff: Lowest sequence score
           * and domain score of match in the full alignment. NC Noise Cutoff:
           * Highest sequence score and domain score of match not in full
           * alignment. TP Type: Type of family -- presently Family, Domain,
           * Motif or Repeat. SQ Sequence: Number of sequences in alignment. AM
           * Alignment Method The order ls and fs hits are aligned to the model
           * to build the full align. // End of alignment.
           * 
           * Optional fields: ----------------
           * 
           * DC Database Comment: Comment about database reference. DR Database
           * Reference: Reference to external database. RC Reference Comment:
           * Comment about literature reference. RN Reference Number: Reference
           * Number. RM Reference Medline: Eight digit medline UI number. RT
           * Reference Title: Reference Title. RA Reference Author: Reference
           * Author RL Reference Location: Journal location. PI Previous
           * identifier: Record of all previous ID lines. KW Keywords: Keywords.
           * CC Comment: Comments. NE Pfam accession: Indicates a nested domain.
           * NL Location: Location of nested domains - sequence ID, start and
           * end of insert.
           * 
           * Obsolete fields: ----------- AL Alignment method of seed: The
           * method used to align the seed members.
           */
          // Let's save the annotations, maybe we'll be able to do something
          // with them later...
          Regex an = new Regex("(\\w+)\\s*(.*)");
          if (an.search(annContent))
          {
            if (an.stringMatched(1).equals("NH"))
            {
              treeString.append(an.stringMatched(2));
            }
            else if (an.stringMatched(1).equals("TN"))
            {
              if (treeString.length() > 0)
              {
                if (treeName == null)
                {
                  treeName = "Tree " + (getTreeCount() + 1);
                }
                addNewickTree(treeName, treeString.toString());
              }
              treeName = an.stringMatched(2);
              treeString = new StringBuffer();
            }
            // TODO: JAL-3532 - this is where GF comments and database
            // references are lost
            // suggest overriding this method for Stockholm files to catch and
            // properly
            // process CC, DR etc into multivalued properties
            setAlignmentProperty(an.stringMatched(1), an.stringMatched(2));
          }
        }
        else if (annType.equals("GS"))
        {
          // Generic per-Sequence annotation, free text
          /*
           * Pfam uses these features: Feature Description ---------------------
           * ----------- AC <accession> ACcession number DE <freetext>
           * DEscription DR <db>; <accession>; Database Reference OS <organism>
           * OrganiSm (species) OC <clade> Organism Classification (clade, etc.)
           * LO <look> Look (Color, etc.)
           */
          if (s.search(annContent))
          {
            String acc = s.stringMatched(1);
            String type = s.stringMatched(2);
            String content = s.stringMatched(3);
            // TODO: store DR in a vector.
            // TODO: store AC according to generic file db annotation.
            Hashtable ann;
            if (seqAnn.containsKey(acc))
            {
              ann = (Hashtable) seqAnn.get(acc);
            }
            else
            {
              ann = new Hashtable();
            }
            ann.put(type, content);
            seqAnn.put(acc, ann);
          }
          else
          {
            // throw new IOException("Error parsing " + line);
            System.err.println(">> missing annotation: " + line);
          }
        }
        else if (annType.equals("GC"))
        {
          // Generic per-Column annotation, exactly 1 char per column
          // always need a label.
          if (x.search(annContent))
          {
            // parse out and create alignment annotation directly.
            parseAnnotationRow(annotations, x.stringMatched(1),
                    x.stringMatched(2));
          }
        }
        else if (annType.equals("GR"))
        {
          // Generic per-Sequence AND per-Column markup, exactly 1 char per
          // column
          /*
           * Feature Description Markup letters ------- -----------
           * -------------- SS Secondary Structure [HGIEBTSCX] SA Surface
           * Accessibility [0-9X] (0=0%-10%; ...; 9=90%-100%) TM TransMembrane
           * [Mio] PP Posterior Probability [0-9*] (0=0.00-0.05; 1=0.05-0.15;
           * *=0.95-1.00) LI LIgand binding [*] AS Active Site [*] IN INtron (in
           * or after) [0-2]
           */
          if (s.search(annContent))
          {
            String acc = s.stringMatched(1);
            String type = s.stringMatched(2);
            String oseq = s.stringMatched(3);
            /*
             * copy of annotation field that may be processed into whitespace chunks
             */
            String seq = new String(oseq);

            Hashtable ann;
            // Get an object with all the annotations for this sequence
            if (seqAnn.containsKey(acc))
            {
              // logger.debug("Found annotations for " + acc);
              ann = (Hashtable) seqAnn.get(acc);
            }
            else
            {
              // logger.debug("Creating new annotations holder for " + acc);
              ann = new Hashtable();
              seqAnn.put(acc, ann);
            }

            // // start of block for appending annotation lines for wrapped
            // stokchholm file
            // TODO test structure, call parseAnnotationRow with vector from
            // hashtable for specific sequence

            Hashtable features;
            // Get an object with all the content for an annotation
            if (ann.containsKey("features"))
            {
              // logger.debug("Found features for " + acc);
              features = (Hashtable) ann.get("features");
            }
            else
            {
              // logger.debug("Creating new features holder for " + acc);
              features = new Hashtable();
              ann.put("features", features);
            }

            Hashtable content;
            if (features.containsKey(this.id2type(type)))
            {
              // logger.debug("Found content for " + this.id2type(type));
              content = (Hashtable) features.get(this.id2type(type));
            }
            else
            {
              // logger.debug("Creating new content holder for " +
              // this.id2type(type));
              content = new Hashtable();
              features.put(this.id2type(type), content);
            }
            String ns = (String) content.get(ANNOTATION);

            if (ns == null)
            {
              ns = "";
            }
            // finally, append the annotation line
            ns += seq;
            content.put(ANNOTATION, ns);
            // // end of wrapped annotation block.
            // // Now a new row is created with the current set of data

            Hashtable strucAnn;
            if (seqAnn.containsKey(acc))
            {
              strucAnn = (Hashtable) seqAnn.get(acc);
            }
            else
            {
              strucAnn = new Hashtable();
            }

            Vector<AlignmentAnnotation> newStruc = new Vector<>();
            parseAnnotationRow(newStruc, type, ns);
            for (AlignmentAnnotation alan : newStruc)
            {
              alan.visible = false;
            }
            // new annotation overwrites any existing annotation...

            strucAnn.put(type, newStruc);
            seqAnn.put(acc, strucAnn);
          }
          // }
          else
          {
            System.err.println(
                    "Warning - couldn't parse sequence annotation row line:\n"
                            + line);
            // throw new IOException("Error parsing " + line);
          }
        }
        else
        {
          throw new IOException(MessageManager.formatMessage(
                  "exception.unknown_annotation_detected", new String[]
                  { annType, annContent }));
        }
      }
    }
    if (treeString.length() > 0)
    {
      if (treeName == null)
      {
        treeName = "Tree " + (1 + getTreeCount());
      }
      addNewickTree(treeName, treeString.toString());
    }
  }

  /**
   * Demangle an accession string and guess the originating sequence database
   * for a given sequence
   * 
   * @param seqO
   *          sequence to be annotated
   * @param dbr
   *          Accession string for sequence
   * @param dbsource
   *          source database for alignment (PFAM or RFAM)
   */
  private void guessDatabaseFor(Sequence seqO, String dbr, String dbsource)
  {
    DBRefEntry dbrf = null;
    List<DBRefEntry> dbrs = new ArrayList<>();
    String seqdb = "Unknown", sdbac = "" + dbr;
    int st = -1, en = -1, p;
    if ((st = sdbac.indexOf("/")) > -1)
    {
      String num, range = sdbac.substring(st + 1);
      sdbac = sdbac.substring(0, st);
      if ((p = range.indexOf("-")) > -1)
      {
        p++;
        if (p < range.length())
        {
          num = range.substring(p).trim();
          try
          {
            en = Integer.parseInt(num);
          } catch (NumberFormatException x)
          {
            // could warn here that index is invalid
            en = -1;
          }
        }
      }
      else
      {
        p = range.length();
      }
      num = range.substring(0, p).trim();
      try
      {
        st = Integer.parseInt(num);
      } catch (NumberFormatException x)
      {
        // could warn here that index is invalid
        st = -1;
      }
    }
    if (dbsource == null)
    {
      // make up an origin based on whether the sequence looks like it is
      // nucleotide
      // or protein
      dbsource = (seqO.isProtein()) ? "PFAM" : "RFAM";
    }
    if (dbsource.equals("PFAM"))
    {
      seqdb = "UNIPROT";
      if (sdbac.indexOf(".") > -1)
      {
        // strip of last subdomain
        sdbac = sdbac.substring(0, sdbac.indexOf("."));
        dbrf = jalview.util.DBRefUtils.parseToDbRef(seqO, seqdb, dbsource,
                sdbac);
        if (dbrf != null)
        {
          dbrs.add(dbrf);
        }
      }
      dbrf = jalview.util.DBRefUtils.parseToDbRef(seqO, dbsource, dbsource,
              dbr);
      if (dbr != null)
      {
        dbrs.add(dbrf);
      }
    }
    else
    {
      seqdb = "EMBL"; // total guess - could be ENA, or something else these
                      // days
      if (sdbac.indexOf(".") > -1)
      {
        // strip off last subdomain
        sdbac = sdbac.substring(0, sdbac.indexOf("."));
        dbrf = jalview.util.DBRefUtils.parseToDbRef(seqO, seqdb, dbsource,
                sdbac);
        if (dbrf != null)
        {
          dbrs.add(dbrf);
        }
      }

      dbrf = jalview.util.DBRefUtils.parseToDbRef(seqO, dbsource, dbsource,
              dbr);
      if (dbrf != null)
      {
        dbrs.add(dbrf);
      }
    }
    if (st != -1 && en != -1)
    {
      for (DBRefEntry d : dbrs)
      {
        jalview.util.MapList mp = new jalview.util.MapList(
                new int[]
                { seqO.getStart(), seqO.getEnd() }, new int[] { st, en }, 1,
                1);
        jalview.datamodel.Mapping mping = new Mapping(mp);
        d.setMap(mping);
      }
    }
  }

  protected static AlignmentAnnotation parseAnnotationRow(
          Vector<AlignmentAnnotation> annotation, String label,
          String annots)
  {
    String convert1, convert2 = null;

    // convert1 = OPEN_PAREN.replaceAll(annots);
    // convert2 = CLOSE_PAREN.replaceAll(convert1);
    // annots = convert2;

    String type = label;
    if (label.contains("_cons"))
    {
      type = (label.indexOf("_cons") == label.length() - 5)
              ? label.substring(0, label.length() - 5)
              : label;
    }
    boolean ss = false, posterior = false;
    type = id2type(type);

    boolean isrnass = false;
    if (type.equalsIgnoreCase("secondary structure"))
    {
      ss = true;
      isrnass = !NOT_RNASS.search(annots); // sorry about the double negative
                                           // here (it's easier for dealing with
                                           // other non-alpha-non-brace chars)
    }
    if (type.equalsIgnoreCase("posterior probability"))
    {
      posterior = true;
    }
    // decide on secondary structure or not.
    Annotation[] els = new Annotation[annots.length()];
    for (int i = 0; i < annots.length(); i++)
    {
      String pos = annots.substring(i, i + 1);
      Annotation ann;
      ann = new Annotation(pos, "", ' ', 0f); // 0f is 'valid' null - will not
      // be written out
      if (ss)
      {
        // if (" .-_".indexOf(pos) == -1)
        {
          if (isrnass && RNASS_BRACKETS.indexOf(pos) >= 0)
          {
            ann.secondaryStructure = Rna.getRNASecStrucState(pos).charAt(0);
            ann.displayCharacter = "" + pos.charAt(0);
          }
          else
          {
            ann.secondaryStructure = ResidueProperties.getDssp3state(pos)
                    .charAt(0);

            if (ann.secondaryStructure == pos.charAt(0))
            {
              ann.displayCharacter = ""; // null; // " ";
            }
            else
            {
              ann.displayCharacter = " " + ann.displayCharacter;
            }
          }
        }

      }
      if (posterior && !ann.isWhitespace()
              && !Comparison.isGap(pos.charAt(0)))
      {
        float val = 0;
        // symbol encodes values - 0..*==0..10
        if (pos.charAt(0) == '*')
        {
          val = 10;
        }
        else
        {
          val = pos.charAt(0) - '0';
          if (val > 9)
          {
            val = 10;
          }
        }
        ann.value = val;
      }

      els[i] = ann;
    }
    AlignmentAnnotation annot = null;
    Enumeration<AlignmentAnnotation> e = annotation.elements();
    while (e.hasMoreElements())
    {
      annot = e.nextElement();
      if (annot.label.equals(type))
      {
        break;
      }
      annot = null;
    }
    if (annot == null)
    {
      annot = new AlignmentAnnotation(type, type, els);
      annotation.addElement(annot);
    }
    else
    {
      Annotation[] anns = new Annotation[annot.annotations.length
              + els.length];
      System.arraycopy(annot.annotations, 0, anns, 0,
              annot.annotations.length);
      System.arraycopy(els, 0, anns, annot.annotations.length, els.length);
      annot.annotations = anns;
      // System.out.println("else: ");
    }
    return annot;
  }

  private String dbref_to_ac_record(DBRefEntry ref)
  {
    return ref.getSource().toString() + " ; "
            + ref.getAccessionId().toString();
  }

  @Override
  public String print(SequenceI[] s, boolean jvSuffix)
  {
    out = new StringBuffer();
    out.append("# STOCKHOLM 1.0");
    out.append(newline);

    // find max length of id
    int max = 0;
    int maxid = 0;
    int in = 0;
    int slen = s.length;
    SequenceI seq;
    Hashtable<String, String> dataRef = null;
    boolean isAA = s[in].isProtein();
    while ((in < slen) && ((seq = s[in]) != null))
    {
      String tmp = printId(seq, jvSuffix);
      max = Math.max(max, seq.getLength());

      if (tmp.length() > maxid)
      {
        maxid = tmp.length();
      }
      List<DBRefEntry> seqrefs = seq.getDBRefs();
      int ndb;
      if (seqrefs != null && (ndb = seqrefs.size()) > 0)
      {
        if (dataRef == null)
        {
          dataRef = new Hashtable<>();
        }
        List<DBRefEntry> primrefs = seq.getPrimaryDBRefs();
        if (primrefs.size() >= 1)
        {
          dataRef.put(tmp, dbref_to_ac_record(primrefs.get(0)));
        }
        else
        {
          for (int idb = 0; idb < seq.getDBRefs().size(); idb++)
          {
            DBRefEntry dbref = seq.getDBRefs().get(idb);
            dataRef.put(tmp, dbref_to_ac_record(dbref));
            // if we put in a uniprot or EMBL record then we're done:
            if (isAA && DBRefSource.UNIPROT
                    .equals(DBRefUtils.getCanonicalName(dbref.getSource())))
            {
              break;
            }
            if (!isAA && DBRefSource.EMBL
                    .equals(DBRefUtils.getCanonicalName(dbref.getSource())))
            {
              break;
            }
          }
        }
      }
      in++;
    }
    maxid += 9;
    int i = 0;

    // output database type
    if (al.getProperties() != null)
    {
      if (!al.getProperties().isEmpty())
      {
        Enumeration key = al.getProperties().keys();
        Enumeration val = al.getProperties().elements();
        while (key.hasMoreElements())
        {
          out.append("#=GF " + key.nextElement() + " " + val.nextElement());
          out.append(newline);
        }
      }
    }

    // output database accessions
    if (dataRef != null)
    {
      Enumeration<String> en = dataRef.keys();
      while (en.hasMoreElements())
      {
        Object idd = en.nextElement();
        String type = dataRef.remove(idd);
        out.append(new Format("%-" + (maxid - 2) + "s")
                .form("#=GS " + idd.toString() + " "));
        if (isAA && type.contains("UNIPROT")
                || (!isAA && type.contains("EMBL")))
        {

          out.append(" AC " + type.substring(type.indexOf(";") + 1));
        }
        else
        {
          out.append(" DR " + type + " ");
        }
        out.append(newline);
      }
    }

    // output annotations
    while (i < slen && (seq = s[i]) != null)
    {
      AlignmentAnnotation[] alAnot = seq.getAnnotation();
      if (alAnot != null)
      {
        Annotation[] ann;
        for (int j = 0, nj = alAnot.length; j < nj; j++)
        {

          String key = type2id(alAnot[j].label);
          boolean isrna = alAnot[j].isValidStruc();

          if (isrna)
          {
            // hardwire to secondary structure if there is RNA secondary
            // structure on the annotation
            key = "SS";
          }
          if (key == null)
          {

            continue;
          }

          // out.append("#=GR ");
          out.append(new Format("%-" + maxid + "s").form(
                  "#=GR " + printId(seq, jvSuffix) + " " + key + " "));
          ann = alAnot[j].annotations;
          String sseq = "";
          for (int k = 0, nk = ann.length; k < nk; k++)
          {
            sseq += outputCharacter(key, k, isrna, ann, seq);
          }
          out.append(sseq);
          out.append(newline);
        }
      }

      out.append(new Format("%-" + maxid + "s")
              .form(printId(seq, jvSuffix) + " "));
      out.append(seq.getSequenceAsString());
      out.append(newline);
      i++;
    }

    // alignment annotation
    AlignmentAnnotation aa;
    AlignmentAnnotation[] an = al.getAlignmentAnnotation();
    if (an != null)
    {
      for (int ia = 0, na = an.length; ia < na; ia++)
      {
        aa = an[ia];
        if (aa.autoCalculated || !aa.visible || aa.sequenceRef != null)
        {
          continue;
        }
        String sseq = "";
        String label;
        String key = "";
        if (aa.label.equals("seq"))
        {
          label = "seq_cons";
        }
        else
        {
          key = type2id(aa.label.toLowerCase(Locale.ROOT));
          if (key == null)
          {
            label = aa.label;
          }
          else
          {
            label = key + "_cons";
          }
        }
        if (label == null)
        {
          label = aa.label;
        }
        label = label.replace(" ", "_");

        out.append(
                new Format("%-" + maxid + "s").form("#=GC " + label + " "));
        boolean isrna = aa.isValidStruc();
        for (int j = 0, nj = aa.annotations.length; j < nj; j++)
        {
          sseq += outputCharacter(key, j, isrna, aa.annotations, null);
        }
        out.append(sseq);
        out.append(newline);
      }
    }

    out.append("//");
    out.append(newline);

    return out.toString();
  }

  /**
   * add an annotation character to the output row
   * 
   * @param seq
   * @param key
   * @param k
   * @param isrna
   * @param ann
   * @param sequenceI
   */
  private char outputCharacter(String key, int k, boolean isrna,
          Annotation[] ann, SequenceI sequenceI)
  {
    char seq = ' ';
    Annotation annot = ann[k];
    String ch = (annot == null)
            ? ((sequenceI == null) ? "-"
                    : Character.toString(sequenceI.getCharAt(k)))
            : (annot.displayCharacter == null
                    ? String.valueOf(annot.secondaryStructure)
                    : annot.displayCharacter);
    if (ch == null)
    {
      ch = " ";
    }
    if (key != null && key.equals("SS"))
    {
      char ssannotchar = ' ';
      boolean charset = false;
      if (annot == null)
      {
        // sensible gap character
        ssannotchar = ' ';
        charset = true;
      }
      else
      {
        // valid secondary structure AND no alternative label (e.g. ' B')
        if (annot.secondaryStructure > ' ' && ch.length() < 2)
        {
          ssannotchar = annot.secondaryStructure;
          charset = true;
        }
      }
      if (charset)
      {
        return (ssannotchar == ' ' && isrna) ? '.' : ssannotchar;
      }
    }

    if (ch.length() == 0)
    {
      seq = '.';
    }
    else if (ch.length() == 1)
    {
      seq = ch.charAt(0);
    }
    else if (ch.length() > 1)
    {
      seq = ch.charAt(1);
    }

    return (seq == ' ' && key != null && key.equals("SS") && isrna) ? '.'
            : seq;
  }

  public String print()
  {
    out = new StringBuffer();
    out.append("# STOCKHOLM 1.0");
    out.append(newline);
    print(getSeqsAsArray(), false);

    out.append("//");
    out.append(newline);
    return out.toString();
  }

  private static Hashtable typeIds = null;

  static
  {
    if (typeIds == null)
    {
      typeIds = new Hashtable();
      typeIds.put("SS", "Secondary Structure");
      typeIds.put("SA", "Surface Accessibility");
      typeIds.put("TM", "transmembrane");
      typeIds.put("PP", "Posterior Probability");
      typeIds.put("LI", "ligand binding");
      typeIds.put("AS", "active site");
      typeIds.put("IN", "intron");
      typeIds.put("IR", "interacting residue");
      typeIds.put("AC", "accession");
      typeIds.put("OS", "organism");
      typeIds.put("CL", "class");
      typeIds.put("DE", "description");
      typeIds.put("DR", "reference");
      typeIds.put("LO", "look");
      typeIds.put("RF", "Reference Positions");

    }
  }

  protected static String id2type(String id)
  {
    if (typeIds.containsKey(id))
    {
      return (String) typeIds.get(id);
    }
    System.err.println(
            "Warning : Unknown Stockholm annotation type code " + id);
    return id;
  }

  protected static String type2id(String type)
  {
    String key = null;
    Enumeration e = typeIds.keys();
    while (e.hasMoreElements())
    {
      Object ll = e.nextElement();
      if (typeIds.get(ll).toString().equalsIgnoreCase(type))
      {
        key = (String) ll;
        break;
      }
    }
    if (key != null)
    {
      return key;
    }
    System.err.println(
            "Warning : Unknown Stockholm annotation type: " + type);
    return key;
  }

  /**
   * make a friendly ID string.
   * 
   * @param dataName
   * @return truncated dataName to after last '/'
   */
  private String safeName(String dataName)
  {
    int b = 0;
    while ((b = dataName.indexOf("/")) > -1 && b < dataName.length())
    {
      dataName = dataName.substring(b + 1).trim();

    }
    int e = (dataName.length() - dataName.indexOf(".")) + 1;
    dataName = dataName.substring(1, e).trim();
    return dataName;
  }
}
