### Changes in UGENE v. 50

- Primer3 can be run without a target sequence.
- Primer-BLAST has been implemented in UGENE.
- The hairpin visualization tool mfold has been integrated into UGENE.
- The PlasMapper plasmids annotation database has been updated to the latest version.
- Python, included in the UGENE package, has been upgraded to version 3.
- The list of presets for Primer3 has been expanded.
- Improved compatibility with theme settings in macOS.
- Fixed issues related to the stability and usability of UGENE.

The complete list of changes can be found on the UGENE website.

See also a new video about recent improvements in UGENE.

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